Laboratorio de Estructura e Interacciones de Biomoléculas

Estudiantes motivados/as, becarios doctorales y postdoctorales interesados/as contactarse con el Dr. Santiago Di Lella.

1- Interaction of the small-molecule kinase inhibitors tofacitinib and lapatinib with membranes. 

Haralampiev I, Alonso de Armiño DJ, Luck M, Fischer M, Abel T, Huster D, Di Lella S, Scheidt H, Müller P. BBA Biomembranes. 2020. 183414. doi: 10.1016/j.bbamem.2020.183414.

2- The Structural Biology of Galectin-Ligand Recognition: Current Advances in Modeling Tools, Protein Engineering, and Inhibitor Design. 

Modenutti CP, Capurro JIB, Di Lella S, Martí MA. Front Chem. 2019 Dec 3;7:823. doi: 10.3389/fchem.2019.00823. eCollection 2019. PMID: 31850312 Free PMC article. Review. 

3- Modulation of the pH Stability of Influenza Virus Hemagglutinin: A Host Cell Adaptation Strategy. 

Di Lella S, Herrmann A, Mair CM. Biophys J. 2016 Jun 7;110(11):2293-2301. doi: 10.1016/j.bpj.2016.04.035. PMID: 27276248 Free PMC article. Review. 

4- Lacking catalase, a protistan parasite draws on its photosynthetic ancestry to complete an antioxidant repertoire with ascorbate peroxidase. 

Schott EJ, Di Lella S, Bachvaroff TR, Amzel LM, Vasta GR. BMC Evol Biol. 2019 Jul 19;19(1):146. doi: 10.1186/s12862-019-1465-5. PMID: 31324143 Free PMC article. 

5- Structural determinants of the interaction between influenza A virus matrix protein M1 and lipid membranes. 

Höfer CT, Di Lella S, Dahmani I, Jungnick N, Bordag N, Bobone S, Huang Q, Keller S, Herrmann A, Chiantia S. Biochim Biophys Acta Biomembr. 2019 Jun 1;1861(6):1123-1134. doi: 10.1016/j.bbamem.2019.03.013. Epub 2019 Mar 20. PMID: 30902626 Free article. 

6- Anti-Hemagglutinin Antibody Derived Lead Peptides for Inhibitors of Influenza Virus Binding. 

Memczak H, Lauster D, Kar P, Di Lella S, Volkmer R, Knecht V, Herrmann A, Ehrentreich-Förster E, Bier FF, Stöcklein WF. PLoS One. 2016 Jul 14;11(7):e0159074. doi: 10.1371/journal.pone.0159074. eCollection 2016. PMID: 27415624 Free PMC article. 

7- An adipose tissue galectin controls endothelial cell function via preferential recognition of 3-fucosylated glycans. 

Maller SM, Cagnoni AJ, Bannoud N, Sigaut L, Pérez Sáez JM, Pietrasanta LI, Yang RY, Liu FT, Croci DO, Di Lella S, Sundblad V, Rabinovich GA, Mariño KV. FASEB J. 2020 Jan;34(1):735-753. doi: 10.1096/fj.201901817R. Epub 2019 Nov 26. PMID: 31914594 

8- Impact of human galectin-1 binding to saccharide ligands on dimer dissociation kinetics and structure. 

Romero JM, Trujillo M, Estrin DA, Rabinovich GA, Di Lella S. Glycobiology. 2016 Dec;26(12):1317-1327. doi: 10.1093/glycob/cww052. Epub 2016 May 24. PMID: 27222530

–  Subsidio de reinstalación de la Fundación Alexander-von-Humboldt, Alemania, 2017-2019, “Multivalent studies on Galectin-1”.

–  Sociedad de Investigacion Alemana – DFG, en calidad de Asociado Internacional “Mercator Fellow”, 2018 a 2021,“Characterizing the Interaction of Small-Molecule Kinase Inhibitors with Membranes to Understand their Specific Cellular Effects”.